USING DNA REPAIR ENZYMES BEFORE LED LIGHT THERAPY

A client’s experience, his own research on using DNA Repair Enzymes before LED therapy, Daniel has been a client of ours for years and his knowledge and experience is invaluable and as we work with

him on his skin journey he teaches us so much.

“You all know from my past little blogs how much I adore my skin care and treatments I get in clinic with Nurse Jacqui. Your daily life bombards your skin with stressors UV rays, pollution, even blue

light from our mobiles! Yikes. Now our bodies are incredible and are constantly trying to rebuild and repair but they can be overwhelmed. Our skin over the years gets exposed to more damaging factors

that can lead to cellular DNA damage that causes premature aging, hyperpigmentation, and other skin issues. I’m sure you have all heard of growth factors, copper peptides, retinoids etc. These all

help to support the skin to rejuvenate and renew itself. There is one area of skin repair ingredients called DNA Repair Enzymes which are remarkable in its focus on repairing damage and protecting

our DNA within our skin cells.

One brand I adore is PHOTOZYME MD (available in the Medifine online store) as it’s a well formulated range of products. Each product is designed to help with ageing skin but also to help with DNA Repair. This is not a range you will see immediate results from but week after week you will notice subtle changes in your skins ability to battle aggressors and rejuvenate itself as the DNA are slowly repairing. So over prolonged use I saw a massive difference.

If you to want to read more on DNA repair enzymes look up Dr Ron Moy. He has done so much research into these repair enzymes. Also, the science behind DNA repair was affirmed by the 2015

Nobel Prize in Chemistry, awarded for studies in DNA repair.!!

Why I like PHOTOZYME MD skin care

PHOTOZYME MD utilizes a unique DNA Enzyme Technology; to deliver natural, plant-derived repair enzymes deep into your skin's cells using liposomal encapsulation. This system allows the enzymes to reach the target area by getting the enzymes through the skins barrier. Once inside, the enzymes intelligently seek out and attach themselves to damaged DNA strands caused by photodamage. Your body’s natural repair process is then stimulated to fix the error, removing the damaged segment and replicating a healthy DNA strand.

PHOTOZYME MD products typically include a blend of these three key DNA repair enzymes:

Photolyase: This light-activated enzyme, derived from plankton, specifically targets UV-induced DNA lesions called cyclobutane pyrimidine dimers (CPDs).

Mitosomes (Endonuclease): Extracted from the mustard plant, Arabidopsis thaliana, this enzyme enhances your skin's natural nucleotide excision repair (NER) process. Unlike photolyase, it doesn’t require light to work.
Endosomes (Endonuclease): Sourced from a marine microbe, this enzyme also supports the NER pathway, helping to extract a wide range of DNA lesions.

Little tips and tricks

While PHOTOZYME MD enzymes are excellent on their own, pairing them with LED light therapy creates a synergistic effect that supercharges your results.

Here’s how they work together:

Activate photolyase: For PHOTOZYME MD photolyase enzyme, the visible light emitted by an LED device is the catalyst. Applying the serum pre-LED treatment allows the enzyme to absorb the light energy and work at its maximum potential to repair sun-damaged DNA.
Enhance cellular activity: LED light therapy itself works by triggering cellular changes through a process called photobiomodulation (PBM). This stimulation boosts circulation and energy within the cells, which can help the skin better absorb and utilize the DNA repair enzymes.
Accelerate recovery: LED light is known for its ability to speed up the body’s natural healing processes and stimulate collagen production. This makes it an ideal post-procedure treatment to help your skin recover faster from damage or stressors.

When used after applying PHOTOZYME MD it amplifies the reparative work already underway.

How to use PHOTOZYME MD DNA Youth Recovery Pre-LED treatment

For the best results, use PHOTOZYME MD DNA Youth Recovery as a pre-treatment step in your LED therapy routine.

Cleanse: Start with clean, dry skin.
Apply PHOTOZYME MD DNA Youth Recovery Serum: Dispense a small amount of PHOTOZYME MD DNA Youth Recovery Serum onto your fingertips and massage gently until all absorbed. I do wait around 10-20 mins (recommended) to allow it to fully penetrate my skin. I also can do this at any time of the day! In the morning, I will make this my first step do my LED them post treatment apply antioxidant serums. USING DNA-REPAIR ENZYMES BEFORE LED LIGHT THERPAY Vitamin C serum moisturiser and sunscreen. On an evening, I can also do this and then follow post treatment with my Serums / Retinoids etc.
Use LED device: Recommend use with DNA Repair Enzymes with your LED light therapy treatment, as per the device instructions. The light will activate the photolyase enzyme, kicking off the repair process.

Conclusion

So just a little insight into a not very well-known skin anti-ageing ingredient! More skincare brands are starting to incorporate these DNA repair enzymes into their formulations due to the exciting

research. You don’t need to use the products with an LED Light therapy treatment, but it will enhance the results. I’m quite excited that Medifine online store is now stocking the Under Eye LED treatment

mask! I shall be testing it out soon and let you know how I get on. I do think this is an ingredient that we should all try and incorporate into our routines. Not just for

immediate anti-ageing effects but for the long-term repair of these DNA Strands. You will find the range in the Medifine online store.

From Daniel”

Thank you, Daniel, Medifine supports your message and of course we look at evidence that ultimately must support recommendations, and we have added some further information to support

your wonderful insights and personal advice.

What we found out there is clinical evidence supporting the use of DNA repair enzymes before LED light therapy, and it aligns well with use of PHOTOZYME MD DNA Youth Recovery Facial Serum

1. Photolyase + Light Therapy Synergy

A study published in PNAS demonstrated that topical photolyase, when activated by visible light, significantly repaired UVB-induced DNA damage:

40–45% reduction in cyclobutane pyrimidine dimers (CPDs)
Prevented UV-induced immunosuppression, erythema, and sunburn-cell formation
required light activation after enzyme application for full effect [pnas.org]

2. Active Photoprotection Review (2024)

A review in MDPI Life emphasized that DNA repair enzymes like photolyase and T4 endonuclease V offer active photoprotection:

Go beyond sunscreens by repairing DNA damage post-exposure
Shown to reduce actinic keratoses, photoaging, and skin cancer risk
Effective in in vivo models and clinical trials [mdpi.com]

USING DNA-REPAIR ENZYMES BEFORE LED LIGHT THERPAY

3. PHOTOZYME MD

Specific Evidence – While PHOTOZYME MD’s own clinical studies are limited in peer-reviewed journals, product documentation and user testimonials report:

Visible reduction in UV spots and fine lines
Improved skin texture and tone
Contains three DNA repair enzymes: Micrococcus Lysate, Arabidopsis Thaliana Extract, and Plankton Extract

Why DNA Repair Enzymes work well before LED

Photolyase is activated by blue light (400–500 nm), which is often used in LED therapy.
DNA repair enzymes precondition the skin, reducing oxidative stress and enhance healing.
Combining with LED therapy may amplify collagen production and reduce inflammation.

Medifine’s present take is DNA Repair Enzymes are:

Grounded science: Based on decades of molecular biology and dermatology research.
Emerging clinical adoption: Growing use in aesthetic and medical dermatology, especially for sun-damaged, aging, and post-procedure skin.
Breakthrough potential: Especially when paired with LED therapy, retinoids, or antioxidants.

Our recommendation is:

PHOTOZYME MD DNA Youth Recovery Facial serum, this is their hero product and our choice of product before LED light therapy